Brain tumor researchers find their ‘niche’

Brain tumors appear to arise from cancer stem cells (CSCs) that live within microscopic protective “niches” formed by blood vessels in the brain; and disrupting these niches is a promising strategy for eliminating the tumors and preventing them from re-growing, according to results of a study by investigators at St. Jude Children’s Research Hospital. CSCs are cells that continually multiply, acting as the source of tumors.

“The finding that brain CSCs exist in protective vascular (blood vessel) niches helps explain the origin of brain tumors and suggests a new strategy for eliminating them.
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Sur le même thème que "Brain tumor researchers find their ‘niche’"

Vaccine for brain tumors shows promising results

A vaccine for treating a recurrent cancer of the central nervous system that occurs primarily in the brain, known as glioma, has shown promising results in preliminary data from a clinical trial at UCSF Medical Center. Findings from the first group of six patients in the study, being conducted at the UCSF Brain Tumor Research Center, showed that vitespen (trademarked as Oncophage), a vaccine made from the patient’s own tumor, was associated with tumor-specific immune response in patients with recurrent, high-grade glioma. Glioma is a type of primary tumor that arises from the glial cells, the connective tissue cells that surround and support nerve cells. The most common site of involvement of a glioma is the brain. Malignant glioma is currently a fatal disease. [lien] [EN]

Killing brain tumors from within: A ‘Trojan horse’ approach

A new method for targeting malignant brain tumors through inducing the cancerous cells to “commit suicide” has been developed by a team of researchers headed by a Hebrew University of Jerusalem professor of biochemistry. Scientists have pioneered a technique in which a molecule containing long, double-stranded RNA is attached to epidermal growth factor (EGF) and delivered selectively to cells with an abnormally high number of epidermal growth factor receptors (EGFR). This proliferation of EGFR is typical of certain types of cancer cells, including glioblastoma multiforme (GBM), the most lethal form of brain cancer. The nucleic acid-EFG molecule acts as a “guided missile,” explained Prof. Levitzki, which, when injected into the blood stream, is avidly gobbled up by the multiple EGF receptors on the cancer cells. [lien] [EN]

Gene may lead to early onset of brain tumor

People with a particular gene variant may be more likely to develop brain tumors, and at an earlier age, than people without the gene, according to a study published in  Neurology. The study involved 4 people with brain tumors and 8 people with no cancers. All those with tumors had glioblastoma multiforme, the most common type of brain cancer. People with this type of tumor survive an average of 2 to 5 months. Through blood samples, researchers looked at the tumor suppressor TP3 gene. This gene acts as a tumor suppressor and is involved in preventing cancer. People younger than 5 with brain tumors were more likely to have the Pro/Pro variant of the gene than older people with brain tumors or the healthy participants. [lien] [EN]

Cancer Fighting Technology for Brain Tumors

Trilogy Stereotactic Radiation Therapy to treat brain tumors. Trilogy precisely pinpoints the exact location of the cancer and treats it with a highly accurate beam of radiation. [lien] [EN]

HSBC Refunds $35 Fee, Not To Correct Their Mistake, But Because You Have A Deadly Brain Tumor [Complaints]

Brian, who is suffering from an inoperable malignant brain tumor which may kill him in a matter of months, writes he's having with troubles with his Orchard Bank (aka HSBC Bank Card Services) credit... [[ This is a content summary only. Visit my website for full links, other content, and more! ]] [lien] [EN]

Ted Kennedy Has Malignant Brain Tumor [Sad Face]

Doctors have determined that Ted Kennedy, who was hospitalized after a seizure over the weekend, has a malignant brain tumor. They're going to do some more tests to determine a course of action, but average survival appears to be anywhere between less than a year to five years. Too sad. Get well soon, Teddy! We will honor you by linking to your massive, awe-inspiring legislative accomplishments section on Wikipedia, as you watch the Red Sox in the hospital. [AP/MSNBC] [lien] [EN]

Kennedy Has Malignant Brain Tumor

Just breaking: Sen. Edward M. Kennedy has a malignant brain tumor. Doctors for the Massachusetts Democrat say tests conducted after Kennedy suffered a seizure this weekend show a tumor in his left parietal lobe. His treatment will be decided after more tests but the usual course includes combinations of radiation and chemotherapy. Good luck to Sen. Kennedy. [lien] [EN]

Be Nice To Writers Or They'll Give You A Brain Tumor [Careers]

Unless that's what you want. Katherine Heigl may have finally done it. Someone on the inside at her popular show Grey's Anatomy is whispering that Heigl's character, Izzie, will get a brain tumor and possibly die in the upcoming season. “It's their way of screwing with her," the insider says. "She won't know whether she's going to live or die.” Hah! ABC has only confirmed that her former costar Jeffrey Dean Morgan—who played a patient that she loved but sorta killed (right?)—will be back in the saddle for some episodes. The inside source says that he'll be appearing in Izzie's tumor-induced dreams/hallucinations. So yeah, she may have finally pissed off the showrunners enough to get once-and-for-all written off the show, which she seems, foolishly, to be gunning for. [lien] [EN]

Hot-Rodding Columnist Hospitalized With Brain Tumor [Robert Novak]

Last week, conservative columnist Bob Novak ran his car into an 86-year-old homeless man and then drove off, apparently oblivious. Now the 77-year-old journalist has been hospitalized with a brain tumor. Sheesh! Bad week! Anyway no one knows how bad it is yet, though he can still talk and issue statements and so on. And no one knows either whether the tumor caused his bizarre accident, because really it was bound to happen anyway with the way he drives. [Sun-Times] [lien] [EN]

Robert Novak Diagnosed with Brain Tumor

[Guest post by DRJ] Columnist Robert Novak has been diagnosed with a brain tumor. I hope it’s benign, was caught early, and can be treated. This may explain his recent inability to grasp and recall the details of his car/pedestrian accident. Newsbusters points out that the Huffington Post elected to close comments on this topic, which may become the norm when the subject is a conservative with a serious disease. There probably aren’t more brain tumors statistically but I’ve noticed more cases. Ted Kennedy was recently diagnosed and I know several in my community (which may not be unusual since I’ll probably know more people with every disease as I get older). However, I also know more teens with brain tumors and that’s upsetting. Although I was universally criticized the last time we discussed this. [lien] [EN]

Customer: "I Have A Brain Tumor" Apple Rep: "Not My Problem. Okay. So You Want..." [Apple]

You don't have to believe everything customers say to you when you're a customer service rep. You don't even have to actually care. But if you can't stop yourself from slipping in phrases like "not my problem" when you're helping out a customer, maybe you need to try a different career. Like, say, parole officer. This customer wanted to remove his active mobileme address and turn one of his existing email only addresses into his main account. Here's how the chat went: Brian: Hi Sheena! Sheila H: Hello, Brian. Sheila H: I understand you want to switch your main account and email only account, correct? Brian: I have a little problem. I need to switch the main mobileme account to an email only account and switch one of my email only accounts to the main account. Is that possible? Sheila H. [lien] [EN]

Positivity: Brain tumor survivor Taylor Parks returns

From Salem, Virginia: Posted: Friday, October 3, 2008 12:28 pm Taylor Parks went back to school this fall. That might not seem like a big accomplishment for most 14-year-olds, but in Taylor’s case, it’s a miracle. Four years ago in the middle of his season as a Little League pitcher, the fourth-grader was benched with severe headaches, flu-like symptoms and sensitivity to light. He was diagnosed with a rare and aggressive brain tumor. Most of it was successfully removed – and then Taylor went into a coma for eight months. When he work up, he had missed his birthday, his whole fifth-grade year at Glenvar Elementary in Salem, Va., and other ordinary milestones in his family’s life. Scans showed cancer cells seeded around the periphery of his brain. His condition got worse. [lien] [EN]

Senator Ted Kennedy Has a Brain Tumor

From the New York Times/AP:Doctors for the Massachusetts Democrat say tests conducted after Kennedy suffered a seizure this weekend show a tumor in his left parietal lobe. Preliminary results from a biopsy of the brain identified the cause of the seizure as a malignant glioma, they said. His treatment will be decided after more tests but the usual course includes combinations of radiation and chemotherapy. The 76-year-old senator has been hospitalized in Boston since Saturday, when he was airlifted from Cape Cod after a seizure at his home. His wife and children have been with him each day but have made no public statements. His doctors said in a statement released to The Associated Press that he has had no further seizures, is in good spirits and is resting comfortably. Malignant gliomas are a type of brain cancer diagnosed in about 9. [lien] [EN]

That’s Not a Brain Tumor … That’s a Worm!

Rosemary Alvarez went to the doctor because she had numbness in her arms and blurred vision. An MRI revealed something unusual deep in her brain stem, so doctors immediately sent her to surgery. But they didn’t find the tumor they expected - instead, they found … a worm! Doctors removed the worm and don’t believe Alvarez will [...] [lien] [EN]